Long-term effectiveness and safety of sirolimus drug-eluting stents

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Long-term effectiveness and safety of sirolimus drug-eluting stents

The root cause of coronary artery disease is atherosclerosis, ie, intraluminal narrowing (stenosis) of the arteries that supply blood to tissues of the heart. The introduction of the drug-eluting stent over the past decade has revolutionized the field of interventional cardiology. It is used extensively in clinical practice for the treatment of coronary artery disease. The first drug-eluting st...

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The Impact of Renal Impairment on Long-Term Safety and Effectiveness of Drug-Eluting Stents

BACKGROUND Renal impairment (RI) is associated with impaired prognosis in patients with coronary artery disease. Clinical and angiographic outcomes of patients undergoing percutaneous coronary intervention (PCI) with the use of drug-eluting stents (DES) in this patient population are not well established. METHODS We pooled individual data for 5,011 patients from 3 trials with the exclusive an...

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Long-term safety and effectiveness of unprotected left main coronary stenting with drug-eluting stents compared with bare-metal stents.

BACKGROUND Limited information is available on long-term outcomes for patients with unprotected left main coronary artery disease who received drug-eluting stents (DES). METHODS AND RESULTS In the multicenter registry evaluating outcomes among patients with unprotected left main coronary artery stenosis undergoing stenting with either bare metal stents (BMS) or DES, 1217 consecutive patients ...

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Long-term comparison of everolimus-eluting and sirolimus-eluting stents for coronary revascularization.

OBJECTIVES This study sought to compare the unrestricted use of everolimus-eluting stents (EES) with sirolimus-eluting stents (SES) in patients undergoing percutaneous coronary intervention. BACKGROUND It is unclear whether there are differences in safety and efficacy between EES and SES during long-term follow-up. METHODS Using propensity score matching, clinical outcome was compared among...

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Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents.

BACKGROUND The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis, myocardial infarction, and death. Such studies have been inconclusive because of their insufficient size, the use of historical controls, a limited duration of follow-up, and a lack of access to original source data. METHODS We performed a pooled analysis of data from fo...

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ژورنال

عنوان ژورنال: Medical Devices: Evidence and Research

سال: 2011

ISSN: 1179-1470

DOI: 10.2147/mder.s11749